GINKGOLIDE B MAINTAINS CALCIUM HOMEOSTASIS IN HYPOXIC HIPPOCAMPAL NEURONS BY INHIBITING CALCIUM INFLUX AND INTRACELLULAR CALCIUM RELEASE

Ginkgolide B Maintains Calcium Homeostasis in Hypoxic Hippocampal Neurons by Inhibiting Calcium Influx and Intracellular Calcium Release

Ginkgolide B (GB), a terpene lactone and active ingredient of Ginkgo biloba, shows protective effects in neuronal cells subjected to hypoxia.We investigated whether GB might protect neurons from hypoxic injury through regulation of neuronal Ca2+ homeostasis.Primary hippocampal neurons subjected to chemical hypoxia (0.7 mM CoCl2) in vitro exhibited

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Modulation of Ion Channels in the Axon: Mechanisms and Function

The axon is responsible for integrating synaptic signals, generating action potentials (APs), propagating 70 qt storage bin those APs to downstream synapses and converting them into patterns of neurotransmitter vesicle release.This process is mediated by a rich assortment of voltage-gated ion channels whose function can be affected on short and lon

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A fatal case of Perthes syndrome

Perthes syndrome, or traumatic asphyxia, is a clinical syndrome associating cervicofacial cyanosis with cutaneous petechial haemorrhages and subconjonctival shure blx2 h10 bleeding resulting from severe sudden compressive chest trauma.Deep inspiration and a Valsalva maneuver just prior to rapid and severe chest compression, are responsible for the

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